San Francisco evens the series 1-1 behind a solid pitching performance by Ryan Vogelsong and a breakout offensive game by the Giants lineup.
Vogelsong lasted seven innings before turning the game over to the Giants bullpen. He allowed just one run and struck out four.
Meanwhile, San Francisco struck first against Chris Carpenter on a leadoff homer by Angel Pagan to begin the Giants half of the first inning.
San Francisco then added on four runs in the fourth inning, three coming on a bases clearing single by Marco Scutaro, aided by a fielding error by Matt Holliday.
San Francisco put the game out of reach in the eighth inning with an RBI single by Ryan Theriot to score two and push the score to 7-1.
St. Louis scored their only run of the game in the second inning on an RBI double by Carpenter to score Pete Kozma.
Vogelsong earned the win and moved to 1-0 in his postseason career. Carpenter took the loss and moved to 0-1 this postseason and 10-3 for his career in postseason play.
Sergio Romo earned his second save of the postseason and first of this LCS.
Scutaro, injured on a hard slide by Matt Holliday in the first inning, left the game in the sixth inning for x-rays on his hip.
The Giants will send Matt Cain to the mound in Game 3 to take on Kyle Lohse of the Cardinals.
The series heads back to St. Louis and will resume on Wednesday with the series tied at 1-1.